Glutathione is the Master Antioxidant. Each serving size (1 capsule) contains: L-Glutathione (reduced) (free-form) 100 mg. Other ingredients: hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water).

Directions: As a dietary supplement, take 2 capsules daily

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Glutathione Is The Most Powerful Antioxidant & Related To Disc Degeneration & Herniation

Powerful antioxidants related to joint health are a key to prevention of degenerative conditions. To reduce inflammation and cell damage, an antioxidant like Glutathione can neutralize free radicals responsible for oxidative stress that increase risks of age related diseases.[1]

reduced glutathione

Degenerative Disc Disease is a condition that is most responsible for spinal surgery and can result in low back pain and lumbar disc herniation. Factors involved in this condition can be genetic, extrinsic or things like too much compression on the disc, nutrition disruption, injuries and overloads, as well as intrinsic or internal chemical factors.

Therefore, combating spinal degeneration means an approach that includes both biomechanical and biochemical factors for both prevention and relief of subsequent back and neck pain. While antioxidants are available in food like vitamin C, Glutathione is so powerful, it has been called the Master Antioxidant.[2]

It boosts immunity, supports mitochondria energy production, helps protect fat oxidation, and assists healthy brain function[3]. Optimal levels benefit the cardiovascular system, vision, gut and fat burning ability.[4] Insufficient levels are associated with neurodegenerative diseases with increased levels of oxidative stress in the brain.[5] The documented benefits of this natural detoxification agent are numerous, however, we focus on reducing oxidative stress and the relationship for better joint health.

Oxidative stress is related to age associated disc disease.[6] Glutathion has been shown to have a protective effect on disc cells.[7] In a recent study levels were directly related to patients with lumbar disc degeneration.[8] Serum levels of glutathione reductase, the reduced form, were significantly lower in patients with disc degeneration and disc herniation undergoing surgery compared to healthy individuals involved in the study.


In the study conclusion, the authors state, “Oxidative stress mechanisms play a crucial role in disc degeneration and GR [Reduced Glutathione] deficiency could be an eligible risk factor for LDDD [Lumbar Degenerative Disc Disease]”.

So, while the body makes its own, mental and environmental stressors like working a stressful job or breathing dirty city air quickly depletes these stores. Therefore, a supplement can be beneficial for therapeutic reasons. I recommend the reduced form for bioavailability at least 100mg/day – with disc disease, double the dose. You can take more when you are sick or particularly stressed out. I use the Pure Encapsulation, but there are many great picks.

Glutathione References:
1. Presse Med. 2002 Jul 27;31(25):1174-8
2. Pathol Biol (Paris). 1996 Jan;44(1):77-85.
3. Prog Neurobiol. 2000 Dec;62(6):649-71
4. Proc Nutr Soc. 2000 Nov;59(4):595-600
5. Int J Mol Sci. 2013 Oct 18;14(10):21021-44
6. Arch Gerontol Geriatr. 2014 Nov-Dec;59(3):665-9
7. Connect Tissue Res. 2014 Apr;55(2):132-9
8. In Vivo. 2019 May-Jun;33(3):811-814

Author Bio

Stephen Ornstein, D.C. has treated thousands of neck, shoulder and back conditions since graduating Sherman Chiropractic College in 1987 and during his involvement in Martial Arts. He holds certifications as a Peer Review Consultant from New York Chiropractic College, Physiological Therapeutics from National Chiropractic College, Modic Antibiotic Spinal Therapy from Dr. Hanne Albert, PT., MPH., Ph.D., Myofascial Release Techniques from Logan Chiropractic College, and learned Active Release Technique from the founder, P. Michael Leahy, DC, ART, CCSP.