Modic type I change may predict rapid progressive, deforming disc degeneration: a prospective 1-year follow-up study
From: Eur Spine J. 2012 Jan 17. [Epub ahead of print]
This prospective magnetic resonance imaging (MRI) study in chronic low back pain patients evaluated the natural course of degenerative lumbar spine changes in relation to Modic 1 type changes within 1 year. From 3,811 consecutive chronic low back pain patients referred to lumbar spine MRI 54 patients with a large Modic 1 type changes were selected using strict exclusion criteria to exclude specific back disorders. Follow-up MRI was obtained within 11-18 months.
At baseline Modic 1 type changes was associated with an adjacent endplate lesion in 96% of the cases. In follow-up, an unstable Modic 1 type change was associated both with an increase of endplate lesions, decrease of disc height and change in disc signal intensity, most found at L4/5 or L5/S1. In disc spaces without Modic 1 type changes, progression of degenerative changes was rare. Endplate deformation, decreasing disc height and change of disc signal intensity appear essential features of accelerated degenerative process associated with Modic 1 type changes.
